RNA aptamer evaluation using comparative molecular interaction profile analysis system.
نویسندگان
چکیده
In this paper, we introduce a system named Comparative Molecular Interaction Profile Analysis system (CoMIPA) that utilizes virtual docking study for comprehensive analysis of molecular interactions. Research of RNA aptamer is very useful to creation of functional molecules, because RNA aptamer is excellent in binding selectivity and the stability of structure. By using 3-bases RNA fragment, the system can use computational molecular docking results to help for RNA aptamer screening. We believe that the system has the potential to be a useful for RNA aptamer design.
منابع مشابه
Evaluation of the anti-Salmonella Aptamer using Bioinformatic Tools and ELAA Method
Background: Identifying and measuring food pathogens and environmental samples require accurate and high-sensitivity and specific methods. In addition, Salmonella is a zoonotic bacteria that can directly cause human disease. The aim of this work is to develop anti-Salmonella aptamer using bioinformatic tools and enzyme-linked aptamer assay (ELAA) for assessment of affinity and identifying Salmo...
متن کاملMolecular Evaluation using Comparative Molecular Interaction Profile Analysis system
Comparative M olecularInteraction ProfileAnalysis system (CoM IPA) thatutilize virtualdocking study for comprehensive analysis of molecular interactions.The dockingengineuses AutoDock 3.0, which is widely used for docking evaluation of small molecule compound/protein complexes. By using pre-made grid maps for each receptor, the system can evaluate the possibility of these interactions faster.W ...
متن کاملStructure, recognition and adaptive binding in RNA aptamer complexes.
Novel features of RNA structure, recognition and discrimination have been recently elucidated through the solution structural characterization of RNA aptamers that bind cofactors, aminoglycoside antibiotics, amino acids and peptides with high affinity and specificity. This review presents the solution structures of RNA aptamer complexes with adenosine monophosphate, flavin mononucleotide, argin...
متن کاملRNA nanotechnology breakthrough for targeted release of RNA-based drugs using cell-based aptamers
Nucleic acids play different roles besides storing information and proteins coding. For example, single-stranded nucleic acids can fold into complicated structures with capability of molecular detection, catalyzing bioreactions and therapy. The development of RNA-based therapies has been rapidly progressed in the recent years. RNA aptamers are biomolecules with a size of 10 to 50 nm that can be...
متن کاملMolecular evaluation using in silico protein interaction profiles
MOTIVATION To find a correlation between the activities and structures of molecules is one of the most important subjects for molecular evaluation study. Traditional quantitative structure-activity relationship (QSAR) methodologies represent those attempts using physicochemical descriptors. Creating a new molecular description factor based on the results of a computational docking study will ad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Nucleic acids research. Supplement
دوره 3 شماره
صفحات -
تاریخ انتشار 2003